[The role of ozone therapy in prevention of pyoinflammatory complications after transurethral resection of prostatic adenoma].

The study of efficacy of ozone therapy (OT) in preparation of patients with prostatic adenoma (PA) and cystostoma for transurethral resection (TUR) of PA included 20 PA patients with cystostomic drainage who had undergone PA TUR and preoperative preparation with OT sessions. The control group consisted of similar patients but without ozone pretreatment. OT efficacy was assessed by the rate of pyoinflammatory complications (PIC), results of immunological examination, positive changes in prostatic secretion, urine analysis, total blood count, degree ofbacteriuria. In the study group PIC (acute urethritis) developed in 1 patient, in the control--in 6 patients (3 cases of acute urethritis, 2 cases of acute prostatitis and 1 case of acute epididymitis). OT led to lowering of mean values of leukocyturia from 18.1 +/- 0.6 to 14.3 +/- 0.7 on the day of operation, to 10.9 +/- 0.7 after 4 days and to 8.7 +/- 0.6 on postoperative day 8 versus from 18.8 +/- 0.8 to 15.4 +/- 0.7, to 15.8 +/- 0.6 and 13.5 +/- 0.6, respectively. Mean control count of leukocytes in prostatic secretion fell in both groups. OT reduced bacteriuria. Number of bacteria to the day of operation decreased in both groups, but complete elimination of the agent from urine on day 8 was not achieved in the controls. The study group exhibited a rise in the absolute count of blood leukocytes, lymphocytes and ESR diminishing. OT raised significantly the phagocytic count and activity, concentration of mature T-lymphocytes (CD3), T-helpers (CD4), cytotoxic T-lymphocytes (CD8), B-lymphocytes (CD20), T-NK-cells (CD16), T-lymphocyte activation markers (CD3+, CD16+, CD56+, CD3+, CD25+, HLADR+, CD3+. The concentration of IgG, IgM, IgA remained high. Thus, the results of ozone application before PA TUR appeared promising in prevention of postoperative PIC.

[Indirect electrochemical blood oxidation in the prophylaxis of suppurative-inflammatory complications after transurethral resection of the prostate]. / Nepriamoe élektrokhimicheskoe okislenie krovi v profilaktike gnoino-vospalitel'nykh oslozhnenii posle transuretral'noi rezektsii prostaty.

To investigate efficiency of indirect electrochemical blood oxidation in prophylaxis of infectious complications, 28 patients were treated with 0.06% hypochlorite solution (2 infusions, 2-3 days before TURP). These patients belonged to a high-risk group of infectious complications (80% of them had chronic prostatitis, 8 patients had bladder stones, 8 had undergone cystostomy). The results demonstrated that the complication rate in the above prepared patients fell four times as compared to the control group and the postoperati hospital stay was reduced by 3 days.

[Morphofunctional characteristics of erythrocytes in extracorporeal efferent detoxication]. / Morfofunktsional'naia kharakteristika éritrotsitov pri ékstrakorporal'noi éfferentnoi detoksikatsii.

The erythrocyte morphology (scanning electronic microscope, the superficial erythrocyte charge, the lipid peroxidation rate and the blood viscosity were investigated in 78 patients, treated by use of hemodyalisis, hemosorbtion, plasmosorbtion and hyperbaric oxygenation to correct the chronic renal insufficiency and the purulent intoxication. The described erythrocyte changes reflect the features of definite kind of the efferent treatment and the program of its use, the individuality of the patient initial state. The efferent methods of treatment cause significant and mostly differently directed changes in the peripheral red blood. Morphologic and functional parameters of the erythrocytes appear to be important diagnostic criteria of the efficiency of the extracorporal methods of detoxication.

[Morphofunctional characteristics of erythrocytes in chronic kidney failure and purulent intoxication]. / Morfofunktsional'naia kharakteristika éritrotsitov pri khronicheskoi pochechnoi nedostatochnosti i gnoinoi intoksikatsii.

The morphology of blood erythrocytes was examined under a scanning electron microscope and erythrocyte surface charge, lipid peroxidation on erythrocyte membranes, and blood viscosity were studied in 213 urological patients with chronic renal insufficiency (CRI) and purulent intoxication (PI) of different severity. CRI and PI were characterized by morphofunctional changes in erythrocytes, which depended on the type and severity of intoxication. Changes in erythrocyte morphology in CRI and PI were paralleled by a decrease in their negative surface charge and activation of lipid peroxidation. These parameters can serve as diagnostic tests for evaluation of the severity of intoxication.

[Blood viscosity and the erythrocyte charge in patients with chronic kidney failure and suppurative intoxication and during the correction of these conditions by hemosorption and hemodialysis]. / Viazkost' krovi i zariad éritrotstiov u bol'nykh s khronicheskoi pochechnoi nedostatochnost'iu i gnoinoi intoksikatsiei i pri korrektsii étikh sostoianii gemosorbtsiei i gemodalizom.

Examinations of blood samples from healthy subjects and 16 patients suffering from chronic renal failure and purulent intoxication before and after hemodialysis and hemosorption showed changes in blood viscosity and red cell charges in the patients. Blood viscosity diminished following both hemodialysis and hemosorption, whereas red cell electric charge grew after hemodialysis, but fell after hemosorption. Correlations found between the viscosity, red cell charge and concentrations of urea and creatinine suggest a dependence of blood rheology and red cell surface electrostatic properties on azotemic intoxication. Thus, hemodialysis and hemosorption produce diverse effects on physiochemical characteristics of blood.

[The morphological characteristics of the erythrocytes during hemosorption in patients with chronic kidney failure and suppurative intoxication]. / Morfologicheskie osobennosti éritrotsitov pri gemosorbtsii u bol'nykh s khronicheskoi pochechnoi nedostatochnost'iu i gnoinoi intoksikatsiei.

Red blood cells obtained shortly before and after a hemosorption session from 12 patients were studied in scanning electron microscope. The patients suffered from chronic renal failure and purulent intoxication consequent to urolithiasis and purulent pyelonephritis (10 cases), renal arteriosclerosis (1 case) and prostatic cancer (1 case). Before hemosorption number of discocytes measured 50.8%, while that of stomatocytes 37.3%. Spherocytes, echinocytes and knisocytes occurred in larger quantities. After hemosorption diskocytes amounted 67%, echinocytes and acanthocytes levels rose. The changes may be due to normalization of blood biochemistry after the hemosorption, and to sorbent effects on red cells.